Conversations that matter: Better brain health

June 29, 2015

Max Cynader, the founding director of UBC’s Brain Research Centre, talks about the importance of sleep in keeping cognitive function healthy as people age.

“During sleep, you essentially replay some of the events of the day,” Cynader says, “It’s your hippocampus rebroadcasting it out back to the rest of your brain while you’re asleep, giving your neurons a chance to fire together and hence wire together.” This “rehearsal process” helps the brain perform better when the same or similar situations come up.

http://news.ubc.ca/2015/06/29/conversations-that-matter-better-brain-health/

Swedish scientists create an artificial neuron that mimicks an organic one

Could remotely stimulate neurons based on specific chemical signals received from different parts of the body, or doctors could artificially bridge damaged nerve cells and restore neural functions
June 29, 2015

Chemical-to-electrical-to-chemical signal transmission. A conventional neuron (upper panel) senses chemical signals (orange circles), which trigger an electrical pulse of membrane depolarization (action potential) along the axon, causing chemical release at the axon terminals (blue circles). This process can be mimicked (lower panel) by a chemical biosensor (for glutamate or acetylcholine) connected to an axon-mimicking organic electronic ion pump that transmits electrons/ions and generates chemicals — forming an organic electronic biomimetic neuron. (credit: Daniel T. Simon et al./Biosensors and Bioelectronics

Scientists at Sweden’s Karolinska Institutet and Linköping University have built what they claim is a “fully functional neuron” that mimicks the functions of a human nerve cell.

The “organic electronic biomimetic neuron” combines a biosensor and ion pump. It senses a chemical change in one dish and translates it into an electrical/ionic signal that travels along an “axon” to a “synapse” and releases chemical signals in another dish, that then trigger another neuron, etc.

Glutamate drops are added to a dish containing a biosensor (green) that generates electronic signals (e–), which (via hardware/software) regulate hydrogen ion delivery (white tube) to another dish, where pH is monitored microscopically (video) (credit: Daniel T. Simon et al./Biosensors and Bioelectronics)

Such a device could eventually be miniaturized and implantable, says lead investigator Agneta Richter-Dahlfors, Karolinska Institutet professor of cellular microbiology. The research objective: improve treatments for neurological disorders, which are currently limited to traditional electrical stimulation.

Could the brain be analogous to a computer?

Countering skeptics, psychologist/neuroscientist Gary Marcus, writing in The New York Times June 27, says “yes” — but not a simplistic digital or analog computer. “The brain might consist of highly orchestrated sets of fundamental building blocks, such as ‘computational primitives’ for constructing sequences, retrieving information from memory, and routing information between different locations in the brain,” he says. One computational model he suggests: a field programmable gate array (FPGA), consisting of multiple types of “logic blocks” operating in parallel.

For example, the new technique could make it possible to remotely stimulate neurons based on specific chemical signals received from different parts of the body. Or physicians could artificially bridge damaged nerve cells and restore neural functions.

To find out, the scientists would next like to miniaturize this device to enable implantation into the human body and cause it to wirelessly release neurotransmitters in distant neurons, says Richer-Dahlfors. “Such auto-regulated sensing and delivery, or possibly a remote control, [could lead to] new and exciting opportunities for future research and treatment of neurological disorders.”

This study was published in the journal Biosensors & Bioelectronics. Funding was provided by Carl Bennet AB, VINNOVA, Karolinska Institutet, the Swedish Research Council, Swedish Brain Power, Knut and Alice Wallenberg Foundation, the Royal Swedish Academy of Sciences, and Önnesjö Foundation.

Karolinska Institutet | Artificial neuron mimicks function of human cells

Abstract of An organic electronic biomimetic neuron enables auto-regulated neuromodulation

Current therapies for neurological disorders are based on traditional medication and electric stimulation. Here, we present an organic electronic biomimetic neuron, with the capacity to precisely intervene with the underlying malfunctioning signalling pathway using endogenous substances. The fundamental function of neurons, defined as chemical-to-electrical-to-chemical signal transduction, is achieved by connecting enzyme-based amperometric biosensors and organic electronic ion pumps. Selective biosensors transduce chemical signals into an electric current, which regulates electrophoretic delivery of chemical substances without necessitating liquid flow. Biosensors detected neurotransmitters in physiologically relevant ranges of 5–80 µM, showing linear response above 20 µm with approx. 0.1 nA/µM slope. When exceeding defined threshold concentrations, biosensor output signals, connected via custom hardware/software, activated local or distant neurotransmitter delivery from the organic electronic ion pump. Changes of 20 µM glutamate or acetylcholine triggered diffusive delivery of acetylcholine, which activated cells via receptor-mediated signalling. This was observed in real-time by single-cell ratiometric Ca2+ imaging. The results demonstrate the potential of the organic electronic biomimetic neuron in therapies involving long-range neuronal signalling by mimicking the function of projection neurons. Alternatively, conversion of glutamate-induced descending neuromuscular signals into acetylcholine-mediated muscular activation signals may be obtained, applicable for bridging injured sites and active prosthetics.

references:
Daniel T. Simon, Karin C. Larsson, David Nilsson, Gustav Burström, Dagmar Galter, Magnus Berggren, Agneta Richter-Dahlfors. An organic electronic biomimetic neuron enables auto-regulated neuromodulation. Biosensors and Bioelectronics, 2015; 71: 359 DOI: 10.1016/j.bios.2015.04.058
related:
Artifical neuron mimicks function of human cells

http://www.kurzweilai.net/swedish-scientists-create-an-artificial-neuron-that-mimicks-an-organic-one

Creating a better semiconductor in femtoseconds with ‘photo-doping’

June 29, 2015

Certain compounds can exhibit multiple quantum phases, including Mott insulator, superconductor, and spin or charge density wave (CDW) states based on subtle physical tunings, including applying heat, pressure (P), and doping (x) (credit: Tzong-Ru T. Han et al./Science Advances)

Michigan State University (MSU) researchers have developed a “photo-doping” process by shooting an ultrafast laser pulse into a semiconductor* material — rapidly changing its properties as if it had been chemically “doped.”

Changing the electrical properties of semiconductors formerly required a complex, expensive process of adding different dopants, or trace chemical impurities.

The new research could lead to development of next-generation electronic materials and even optically controlled switching devices without requiring doping of semiconductor materials.

“The material we studied is an unconventional semiconductor made of alternating atomically thin layers of metals and insulators,” said Chong-Yu Ruan, an associate professor of physics and astronomy who led the research effort at MSU.

“This combination allows many unusual properties, including highly resistive and also superconducting behaviors to emerge, especially when ‘doped.’”

By varying the wavelengths and intensities of the laser pulses, the researchers were able to observe phases with different properties that are captured on the femtosecond timescale. A femtosecond is 1 quadrillionth, or 1 millionth of 1 billionth, of a second.

“The laser pulses act like dopants that temporarily weaken the glue that binds charges and ions together in the materials at a speed that is ultrafast and allow new electronic phases to spontaneously form to engineer new properties,” Ruan said. “Capturing these processes in the act allows us to understand the physical nature of transformations at the most fundamental level.”

The research is described in a open-access paper published in the journal Science Advances.

* A semiconductor is a substance that conducts electricity under some conditions but not others, making it a good medium for the control of electrical current. Semiconductors are used in many electronic devices, including computers.

Abstract of Exploration of metastability and hidden phases in correlated electron crystals visualized by femtosecond optical doping and electron crystallography

Characterizing and understanding the emergence of multiple macroscopically ordered electronic phases through subtle tuning of temperature, pressure, and chemical doping has been a long-standing central issue for complex materials research. We report the first comprehensive studies of optical doping–induced emergence of stable phases and metastable hidden phases visualized in situ by femtosecond electron crystallography. The electronic phase transitions are triggered by femtosecond infrared pulses, and a temperature–optical density phase diagram is constructed and substantiated with the dynamics of metastable states, highlighting the cooperation and competition through which the macroscopic quantum orders emerge. These results elucidate key pathways of femtosecond electronic switching phenomena and provide an important new avenue to comprehensively investigate optical doping–induced transition states and phase diagrams of complex materials with wide-ranging applications.

references:
Chong-Yu Ruan et al. Exploration of metastability and hidden phases in correlated electron crystals visualized by femtosecond optical doping and electron crystallography. Science Advances, June 2015 DOI: 10.1126/sciadv.1400173 (open access)
related:
Building a better semiconductor

http://www.kurzweilai.net/creating-a-better-semiconductor-in-femtoseconds-with-photo-doping

A fat cat is not a happy cat — and Fido may need to diet

By Tre’vell Anderson
Los Angeles Times

Garfield is not the only fat cat around.

The Association for Pet Obesity Prevention says more than 50 percent of the nation’s cats and dogs are overweight. And just as concerning, more than 90 percent of their owners don’t recognize that their pet is carrying around extra pounds.

“People automatically think a fat cat is a happy cat,” says Ernie Ward, owner of Seaside Animal Care in Calabash, N.C. “But it’s not cute. It’s killing.”

Ward founded the organization in 2005 after realizing that many veterinarians were not talking to pet owners about obesity. Ten years later, he says, vets are finally having those necessary conversations.

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“It’s an emotional land mine,” Ward says. “You don’t know when you’re going to step on the wrong button because people inherently have a problem with questions (about how they’re) feeding pets because we equate love with food and treats.”

Not unlike humans, pets can face obesity because of too much food and too little exercise, says Eve Flores, a veterinarian and co-owner of DTLAvets with Leia Castaneda.

Overweight animals are more prone to a host of health conditions, including arthritis, high blood pressure and blindness.

Below are some suggestions from Ward, Flores and Castaneda for pet owners looking to improve pets’ health.

• Get your pet an annual checkup

• Read labels — don’t buy pet foods with unpronounceable ingredients

• Don’t overfeed

• Exercise your pet

Ward uses a simple equation to get through to his clients: “Fat equals inflammation, which equals disease which equals early death.” To avoid that, exercise is a must, he says. “It is as simple as walking your dog 30 minutes a day, interacting with your cat for five minutes three times a day.”

Flores adds that extending normal walking or play times by 10 minutes can do the trick.

http://www.seattletimes.com/life/pets/a-fat-cat-is-not-a-happy-cat-and-fido-may-need-to-diet/

Research shows ‘sleep sex’ now prevalent in bedrooms

London: Not just sleepwalking or talking, there are some people who are having “sleep sex” as they hit the sack, a British survey has revealed.

The condition is called “sexomnia” where a person engages in sexual activity during sleep.

According to the study by Guy Meadows of The Sleep School and Bensons for Beds, Britain’s leading bed supplier, one in 10 Britons has sleep sex.

“One of the most interesting aspects was that one in 10 people questioned are experiencing the phenomenon of ‘sexomnia’ during their sleep,” Meadows was quoted as saying in a bustle.com report.

For the study, they looked at the sleeping habits of 13,000 adults across Britain.

The team also found that one in 10 people went to the toilet while they were asleep. One in seven admitted to experiencing sleep paralysis and one in 10 even stopped breathing.

The study revealed that while sleepwalking, 16 percent of people have eaten light snacks.

According to Psychology Today, when women experience sleep sex, they typically exhibit “sexual vocalisations” and masturbation.

Men, on the other hand, would engage in fondling and intercourse.

People who suffer from “sexomnia” also show other kinds of sleep disorders such as sleep apnea and sleep deprivation.

One cause of “sexomnia” is a sleep-related epilepsy that can cause a person to experience sexual arousal, pelvic thrusting and orgasms.

Many of us lead hectic and busy lifestyles. It can be hard to really switch off before bed and “as this research reveals, sleep can often be disrupted by restlessness”, Meadows added.

Eating and drinking certain foods and drinks such as alcohol before sleep can act as a stimulant and prevent people from achieving a sound sleep, the researchers concluded.

http://www.ummid.com/news/2015/June/28.06.2015/sleep-sex-bedrooms.html#sthash.PrcAF0px.dpuf

Canadian anti-capitalist Naomi Klein named to Vatican committee to promote environmental conference

Canadian author and environmentalist Naomi Klein, known for her opposition to capitalism and corporate globalization, is scheduled to join a Vatican committee that was formed to draw attention to a conference on the environment being held in Rome this week.

Klein’s most recent book, This Changes Everything: Capitalism vs. the Climate, explores the relationship between economic powers and the environment.

The People and Planet First conference is organized by the Pontifical Council of Justice and Peace and by Catholic groups and will bring together Church leaders and scientists.

In a recent encyclical about the environment, Pope Francis wrote passionately about the world’s moral duty to save the Earth and move away from business systems that pollute.

He also noted how the poor often suffer the most from pollution and from other environmental damage in developing countries.

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On Sunday in St. Peter’s Square, the Pope encouraged people of different religions to work together in caring for the Earth, which he called our “common house.”

Speaking from his window in a Vatican palazzo to tens of thousands of pilgrims and tourists, Francis singled out a few hundred people who had marched to St. Peter’s Square under the banner “One Earth, one family.”

The marchers included Christians, Muslims, Jews, Hindus and others who had walked from near the French embassy to remind people of a key U.N. climate change conference in Paris in December.

“I encourage the collaboration between persons and associations of different religions on behalf of an integral ecology,” Francis said, offering good wishes to young people discussing what he described as “the care of the common house.”

For Francis, efforts to preserve the environment are an excellent way to bring together secular and non-secular forces, and especially members of various religions. Love for the environment also expands his papal agenda of highlighting social justice issues like poverty.

http://news.nationalpost.com/news/world/canadian-anti-capitalist-naomi-klein-named-to-vatican-committee

2 Pi or Not 2 Pi?

Three months ago the world (or at least the geek world) celebrated Pi Day of the Century (3/14/15…). Today (6/28) is another math day: 2π-day, or Tau Day (2π = 6.28319…).
Some say that Tau Day is really the day to celebrate, and that τ(=2π) should be the most prominent constant, not π. It all started in 2001 with the famous opening line of a watershed essay by Bob Palais, a mathematician at the University of Utah:
“I know it will be called blasphemy by some, but I believe that π is wrong.”
Which has given rise in some circles to the celebration of Tau Day—or, as many people say, the one day on which you are allowed to eat two pies.
But is it true that τ is the better constant? In today’s world, it’s quite easy to test, and the Wolfram Language makes this task much simpler. (Indeed, Michael Trott’s recent blog post on dates in pi—itself inspired by Stephen Wolfram’s Pi Day of the Century post—made much use of the Wolfram Language.) I started by looking at 320,000 preprints from arXiv.org to see in practice how many formulas involve 2π rather than π alone, or other multiples of π.
Here is a WordCloud of some formulas containing 2π:

I found that only 18% of formulas considered involve 2π, suggesting that τ, after all, would not be a better choice.
But then why do τ supporters believe that we should switch to this new symbol? One reason is that using τ would make geometry and trigonometry easier to understand and learn. After all, when we learn trigonometry, we don’t measure angles in degrees, but in radians, and there are 2π radians in a circle. This means that 1/4 of a circle corresponds to 1/2 π radians, or π/2, and not a quarter of something! This counterintuitive madness would be resolved by the symbol τ, because every ratio of the circle would have a matching ratio of τ. For example, 1/4 would have an angle of τ/4.

I personally do not have strong feelings against π, and to be honest, I don’t think students would learn trigonometry faster if they were to use τ. Think about the two most important trigonometric functions, sine and cosine. What’s most helpful to remember about them is that sin= cos(2 π) = 1, and sin = cos(π) = –1. I have not only always preferred cosine simply because it’s easier to remember (there are no fractions in π and 2 π), I’ve also always recognized that sine and cosine are different because one is nonzero on integer multiples of π and the other is nonzero on some fractions of it. By using τ instead, this symmetry would be lost, and we would be left with the equalities sin= cos(τ) = 1 and sin = cos = –1.
Given these observations, it seems like choosing τ or π is a personal choice. That’s fair, but it’s not a rigorous approach for determining which constant is more useful.

Even the approach I had at the beginning could lead to the wrong conclusion. The Tau Manifesto, by Michael Hartl, gives some examples of places where 2π is most commonly used:

And indeed, all these formulas would be easier if we used τ. However, those are just six of the vast number of formulas that scientists use regularly, and as I mentioned before, not many mathematical expressions involve 2π. Nevertheless, it could happen that formulas not involving 2π would still be simpler if written in τ. For example, the expression 4 π² would simply become (τ²).
For this reason I looked back at the scientific articles to see whether using τ instead of 2π (and τ/2 instead of π) would make their formulas simpler. For instance, these are some that would be simpler in τ:

And these are some that would not:

Let me now try to explain what I mean by simpler by looking at an example: if I take the term containing π in the bottom-left formula of the Tau Manifesto equation table:

I can replace π with τ/2 using ReplaceAll, and I get:

Just by looking at these two expressions, you can see that the second one is simpler. It’s not just your intuition that tells you that; it’s clear that there are fewer symbols and constants in the replaced expression. We can look at their corresponding TreeForms to demonstrate it explicitly:

To get a numeric difference, we can look at the leaf counts (number of leaves on the trees), which correspond to the number of symbols and constants in the original formulas:

To see whether τ had an overall simplifying impact, I computed the complexity of each formula (defined as their leaf counts, as computed above) involving π that appeared in the articles when using π and τ. To be more precise, I first deleted all the formulas that were either equal to π or 2 π. I felt it would have been unfair to consider those as well because very often, if they appear by themselves, they do not stand for formulas. I then compared the number of times the τ formulas were better with the number of times they were not, and only 43% of the formulas whose complexity changed at all were actually better, meaning that using τ would make more than half of them look more complex. In other words, based on this comparison, we should keep using π. However, this is not the end of the story.
One observation I made is that if an expression gets either more or less complex, it’s likely to have a leaf count that is less than 40. In fact, if you look at the percentage of formulas that are better when using π or τ and that have a number of leaves that is less than a fixed number, you get this picture:

where the x axis represents the upper bound on the number of leaves. This suggests that almost all formulas that become simpler have complexities less than 50, regardless of the symbol we choose.
A more relevant observation is that the situation changes drastically as the complexity of the formulas increases. Already by only considering formulas that have complexities greater than 3, like from earlier, only 48% are simpler in π against 52% that are simpler in τ. The graph below shows how the percentage of formulas that are better in either π or τ changes as a function of the complexity:

As you can see, as the number of leaves exceeds 48, the situation becomes chaotic. This is because only 0.4% of formulas have complexities greater than 50. There are not enough of these for us to deduce anything stable and reasonable about them, and the previous observation tells us that we should not really worry much about them anyway.
What this graph tells me is that in everyday life, and for anything more complex than fairly easy expressions like , we should indeed use τ for simplicity. But there is still something else I have not considered. What about different subjects?
It might be that formulas in physics look simpler in τ, but formulas in other subjects do not. The initial search I made included articles from different subjects; however, I didn’t initially check whether the majority of π-containing formulas were from a limited subset of those subjects, or whether the ones that became simpler with τ were mostly from a limited subset. In fact, if I just restrict analysis to articles in mathematics, the situation becomes the following:

Basically, only 23% of formulas benefit from using τ, and those benefits come only when the complexity is fairly high. For instance, something of this sort:

would be an expression that would be simpler in τ, and you probably have not seen many of this type of expression. This suggests that either scientists in different subjects should use different conventions depending on their field-specific formulas, or that all scientific disciplines should switch to τ even though it does not really make sense for some of them to do so. After all, in a democracy, the majority wins, and it is impossible to accommodate everyone.
However, the above formula shows something else that I want to point out. With τ, it becomes this:

And that is not much of an improvement: even though an expression could be easier in τ, the improvement might be so small that it is irrelevant. Consider for instance these two expressions together with their leaf counts:

And the corresponding expressions in τ:

The first formula is simpler in τ, but the leaf count is only 1/13 smaller than the original complexity, whereas the second expression is simpler in π and the replaced expression is 1/6 higher than the original complexity. In other words, the first case’s improvement was 1/13 and the second’s was -1/6 (the minus sign indicates negative improvement, as the expression in τ was worse). The mean of the vector is –0.044, a negative number, which means that using τ in these two expressions makes the whole vector 0.044 worse, although π and τ each improved one formula.
This vector approach is different from the one-count-per-equation one that I used earlier. It considers quantity of improvement instead of just an either/or binary, and it completely reverses the previous conclusions. I have computed these vectors for formulas having complexities bounded from below in the same way I did in the previous example. What I’ve seen is that the overall improvement in going from π to τ, computed as the mean of these vectors, looks like this as the complexity increases:

where the least worsening, -0.04, is achieved at a complexity of 5. As you can see, the improvement stays below 0 the whole time, meaning that while more formulas may be shorter with τ (depending on the field), on average those length decreases are outweighed by the length increases in the formulas that are getting longer.
To make my point, at the end of this scientific investigation: I think we should be happy with our old friend π and not switch to τ.
I have two final observations. The first is that if we had already lived in a τ world, the conclusion would have been different, and we would have chosen to stick with τ. If our expressions were already in τ and we were investigating whether switching to π would make them simpler, our vector-based graph would look like this:

That difference in behavior is because the vectors used to construct the graphs depend on the original complexities, and so change when the original changes.
This shows that for formulas that have a complexity greater than 2 (most of them do) and for which the complexity is not always greater than 18, the improvement in switching from τ to π would be negative again, suggesting that we should not accept the switch. Unfortunately for supporters of τ, we do not live in a τ world.
The second observation, which was brought to me by Michael Trott, is that 2/3 of the formulas shown in The Tau Manifesto (the green table at the beginning) don’t just have 2π in them, but the complex number 2πi. This suggests that maybe the question I was trying to answer is not the correct one. A better one could be this: would it make sense to have a new symbol τ for the complex number 2πi?
This new convention would require changing from πi to τ/2 as well, but that doesn’t affect the complexity of πi. In general, formulas having a πi term inside would either become simpler or preserve their complexity. To give you an idea, here’s a word cloud of formulas that would become simpler:

Which, after substituting τ= 2πi, become these:

You could argue that the percentage of improved formulas may not be high enough, and changing from 2πi to τ is not worth the effort. What evidence shows, however, is the opposite: of all formulas having a πi term, 75% would be simpler, and the remaining 25% would keep their original complexity—none would get worse. This is a strong point to make, and I am not in the position to do it, but I think the equality τ = 2πi looks more promising (and less historically disruptive) than τ = 2π.
Whatever your opinion on τ, I hope you have a lovely Tau Day. Please enjoy two pi(e)s today—imaginary or otherwise.

2 Pi or Not 2 Pi?

Sundown on Eclipse – Google pushes devs to Android Studio

Google announces that Eclipse Android Developer Tools kit will no longer be officially supported by the company for Android app creation. This afternoon Jamal Eason, Product Manager for Android, made clear that Google would be “ending development and official support for the Android Developer Tools (ADT) in Eclipse at the end of the year.” Both the Eclipse ADT plugin and Android Ant build system will still exist, of course, but Google won’t be lending their help to anyone still using them at the end of December.

It’s time to move on, says Google. You need to change, and you need to change as soon as possible. It’s time to use Android Studio, Google’s newest and most all-inclusive place to create software for Android devices. As shown below, moving projects from one place to the other is relatively straightforward.

Step 1: Inside Android Studio, you’ll go to File – New – Import Project.

Step 2: You’ll select your ADT_Project file folder, wherever that might be fore you on your computer. Here this developer has it in C:\Users\Username\Documents\Eclipse_apps\ADT_Project – easy enough.

Android Studio is here, and has been here, for more than two years.

Was that enough time for you, a developer, to make the transition?

Those of you using NDK may not be super enthusiastic about the change. As Android Police suggests, Android Studio just started supporting C and C++ this past month with version 1.3 and is itself only in 1.3 Beta right this minute.

It’s a preview.

We can expect it to be out in full form by the end of the year.

Hopefully before December.

“Over the next few months,” said Eason, “we [Google] are migrating the rest of the standalone performance tools (e.g. DDMS, Trace Viewer) and building in additional support for the Android NDK into Android Studio.”

Of course those of you that demand to use ADT won’t need to fret. ADT plugin and all related toolsets inside Eclipse are all open source. There’ll almost certainly be supporters out in the wild in the near future – more than there are right now – but no Google.

http://www.slashgear.com/sundown-on-eclipse-google-pushes-devs-to-android-studio-26390786/

PEBBLE TIME AVAILABLE FOR PRE-ORDERS IN CANADA

Pebble Time is finally up for grabs in Canada
Pebble’s third smartwatch model, the $199.99 Pebble Time, is presently being offered for preorders through BestBuy.com and will be dispatched by 20th July. The Time will be the organization’s most costly and highlight filled smartwatch to date, fusing another full-shading e-paper showcase, voice control capacities, seven-day battery life, health tracking and a timetable element that lets clients flip through their past, present and forthcoming occasions in their lives on the watch face.

The Pebble Time, which lives up to expectations with iOS and Android smartphones, was offered first to Kickstarter sponsors yet will now be accessible to everyone. U.S. purchasers can preorder the watch through Best Buy, while universal purchasers can preorder one specifically through Pebble.com.

Best Buy hopes to ship the Pebble Time in Canada no later than July 27th and there will be no extra delivery charges. At 9.5mm, the watch is 20% more slender than the real Pebble and components a battery that will last up to seven days between charges.

Pebble time is available online in black red and white colors. It is priced at the rate of $203. However, Best Buy is pricing the timepiece at $199.99 each. Pebble owners can also choose from more than 8,000 compatible smartphone apps in the Pebble app store to customize their devices.

http://www.i4u.com/2015/06/92720/pebble-time-smart-watch-available-pre-orders-canada

Apple has already started making the iPhone 7, report says

The iPhone 6 and 6 Plus
Apple has started producing units of its next iPhone, which is rumored to be called the iPhone 6s or iPhone 7, according to a new report from Bloomberg.
The new report notes that Apple has started production early. It also further indicates that Apple’s next iPhone will have a Force Touch display, which is a technology that Apple debuted with the Apple Watch and its new MacBook.

Apple’s Force Touch screen is pressure sensitive, which means that it can also tell how hard you’re pressing in addition to being able to detect where you’re tapping and swiping.

This triggers different features on the device. For example, pressing hard on the Apple Watch’s display pulls up the option to change its watch face.

This isn’t the first time we’ve heard that Apple’s next iPhone would have a Force Touch screen. KGI Securities analyst Ming-Chi Kuo, who has an excellent track record when it comes to making predictions around new Apple products, has said in the past that a Force Touch display would be the iPhone 7’s flagship feature.

9to5Mac’s Mark Gurman, who has also proven to be reliable in the past when it comes to Apple rumors, reported in May that Force Touch is coming to the next iPhone. Bloomberg also says it’s reported in 2013 that Apple has been making pressure-sensitive displays for the iPhone.

Bloomberg also reiterates some rumors we’ve heard about Apple’s next iPhone so far – namely that it will come in 4.7 and 5.5-inch size options again and that its design isn’t expected to change very much compared to the iPhone 6.

Other than Force Touch, Apple is expected to make some major improvements to the iPhone’s camera by upping the sensor to 12 megapixels rather than eight, previous reports have indicated.

If Apple has already started producing units of its next iPhone, it could mean the company is on track for a September launch. For the past several years, Apple has unveiled its new iPhone in September and its new iPads in October. We’ll have to wait until the fall to see exactly what Apple has in store.

http://www.businessinsider.in/Apple-has-already-started-making-the-iPhone-7-report-says/articleshow/47844024.cms