http://news.ubc.ca/2016/05/06/how-irritable-are-you/

How irritable are YOU?

UBC Okanagan researchers have developed a short test to assess irritability, reports the Daily Mail.

“[Irritability] often goes with stress, it goes with depression, it goes with anxiety, it goes with anger,” but has so far been difficult to accurately measure, said UBC psychologist Susan Holtzman.

The new quiz, which Holtzman and her colleagues call the Brief Irritability Test or BITe, aims to provide a quick assessment tool.

Similar articles appeared in The Telegraph, Mirror (UK), Metro (UK) and New York Magazine.

http://lifehacker.com/the-best-operating-systems-for-your-raspberry-pi-projec-1774669829

The Best Operating Systems for Your Raspberry Pi Projects

If you’re new to the Raspberry Pi, that tiny $35 computer we all love,there’s a good chance you’ve downloaded (or purchased an SD card that includes) NOOBS. NOOBS makes getting started with Pi easy, and includes a bunch of different operating systems to choose from. Which you should choose depends, of course, on your project. Here’s how to make the right choice.

What Is NOOBS?

http://lifehacker.com/ajax/inset/iframe?id=vimeo-90518800&start=0

The Raspberry Pi itself doesn’t come with an operating system. For that,you need NOOBS, short forNew Out of the Box Software. It’s an operatingsystem manager that makes it easy to download, install, and set up yourRaspberry Pi. When you first boot up NOOBS, you’ll get a selection of OSesto choose from. Which operating systems are available depends on whichmodel of Raspberry Pi you are using. For this guide, we’ll stick to the mostcommon OSesoperating systems available on the newest models of theRaspberry Pi. Right now, that’s Raspbian, OSMC, OpenELEC, Windows IoTCore, and RISC OS.

The Raspberry Pi itself doesn’t come with an operating system. For that,you need NOOBS, short forNew Out of the Box Software. It’s an operatingsystem manager that makes it easy to download, install, and set up yourRaspberry Pi. When you first boot up NOOBS, you’ll get a selection of OSesto choose from. Which operating systems are available depends on whichmodel of Raspberry Pi you are using. For this guide, we’ll stick to the mostcommon OSesoperating systems available on the newest models of theRaspberry Pi. Right now, that’s Raspbian, OSMC, OpenELEC, Windows IoTCore, and RISC OS.

While downloading NOOBS is simple, you can buy an SD card with NOOBSpreinstalled for around $12 at Adafruit. If you prefer the DIY route, thesetup process is very straightforward and you’ll find a full guide over onthe Raspberry Pi site. On the first boot, NOOBS greets you with a selectionof operating systems. You can install as many as you want that’ll fit onyour SD card. Let’s dig into which of those choices is best for yourparticular plans for your Raspberry Pi.

Raspbian Is the Best All-Around Operating System

The Best Operating Systems for Your Raspberry Pi Projects

Raspbian is the “official” operating system of the Raspberry Pi and becauseof that, it’s the one most people will want to start with.

Raspbian is a version of Linux built specifically for the Raspberry Pi. Itcomes packed with all the software you’ll need for every basic task with acomputer. You’ll get LibreOffice as an office suite, a web browser, emailprogram, and some tools to teach programming to kids and adults alike.Heck, it even includes a special (no longer in development) version ofMinecraft. Raspbian is the backbone for pretty much every DIY project outthere, so if you’re looking to make something, Raspbian is most likelywhere you want to start. Because it’s so widely used, it’s also easy to findguides and troubleshooting tips.

If you’re new to Linux, Raspbian will be a little confusing for you. The RpiBeginners wiki is a great starting point, as are the official Raspberry Piresources. Both walk you through everything you need to use Raspbian,from making games to getting a grip on the default programs. If videos aremore your thing, the Raspberry Pi for Beginners YouTube channel hasplenty to watch, as does the Raspberry Pi Tutorials Channel.

OSMC Is the Best, Most Feature-Rich Media Center Software

The Best Operating Systems for Your Raspberry Pi Projects

OSMC (Open Source Media Center) is media center software based on Kodi(formerly XBMC), but it’s easier to set up and use. In fact, it doesn’t looklike Kodi at all, and that’s a good thing. It’s probably the easiest to usemedia center software available on the Pi. If you’re new to media centers oryou’re trying to set one up for non-techy people, OSMC is the one you wantto use.

Compared to Kodi, OSMC features a clean interface that cuts a lot of thecrap out. You get a menu on the left side of the screen that lets you to selectmedia (videos/music/pictures), dig into the settings, or check out otherprograms. It’s all tidy and self explanatory. Of course, you can still installKodi add-ons for media streams and set up remotes so you don’t have touse a keyboard. In fact, OSMC has presets for several popular remotes soyou don’t even need to scratch your head trying to set one up. As for localmedia, you can play videos and photos from USB storage.

OSMC still has plenty of room to tinker, though. It runs a full version ofDebian under the hood, so you can set up SSH, FTP, Samba sharing, andplenty more if you’re an advanced user.

OpenELEC Is a Media Center for People Who Want a Barebones, Speedy Experience

The Best Operating Systems for Your Raspberry Pi Projects

If OSMC doesn’t suit your needs, OpenELEC (Open Embedded LinuxEntertainment Center) is worth a look. OpenELEC is a more direct port ofKodi, so if you’re familiar with Kodi and how it works, you’ll be right athome. Where OSMC is a feature-rich and customizable media center thatcan do whatever you want, OpenELEC is built for one thing: playing media.If you have a ton of movies or music already on a hard drive and just want asimple way to play them on your television, OpenELEC is the way to do it.

We’ve dug into OpenELEC before, but its main appeal is its speed.OpenELEC takes Kodi and cuts out a lot of the customization options tokeep it barebones, fast, and simple. However, it’s not as open as OSMC, soyou can’t make system level changes like altering the Pi’s overclock speedwithout delving into complex menus. OpenELEC also limits access tocertain services, like SSH, so it’s not as easy to set up.

Windows 10 IoT Core Is for Developers Making Connected Devices

The Best Operating Systems for Your Raspberry Pi Projects

Windows 10 IoT is a special version of Windows built for the Raspberry Pi.It is not a full version of Windows. Instead, it’s meant as a developmentplatform for coders and programmers to prototype internet connecteddevices using the Raspberry Pi and Windows 10. Windows 10 IoT is onlycompatible with Windows 10 and you cannot do anything with it unless youhave another computer with Windows 10 installed.

When you first boot into Windows 10 IoT, all you’ll see on your Pi is thescreen above. You can’t control or do anything on the Pi by itself. For that,you’ll need to download and install Visual Studio on your Windows PC.Once you do, you can program and control your Raspberry Pi from VisualStudio in Windows 10. This means you can trigger blinking lights, connectto push buttons, control motors, and countless other things.

To get started using Windows IoT Core, Microsoft has a fantastic collectionof projects that teach you how to use it. Give those projects a look and see ifany are interesting to you to decide if Windows 10 IoT Core is worthinstalling.

RISC OS Is for Anyone Looking to Play with a Completely Different Type of Operating System

The Best Operating Systems for Your Raspberry Pi Projects

If there’s an odd-duck here, it’s RISC OS. RISC OS is not built on Linux, noris it really made help electronics tinkerers prototype. Instead, it’s anoperating system all its own. It’s rather weird too, but it can be fun to playaround with.

RISC OS doesn’t have a lot in common with other operating systems likeLinux, OS X, or even Windows. It was initially designed in 1987 and hasroots in the BBC Micro. RISC OS is much simpler than modern operatingsystems. A single app can take over the whole operating system, it onlyworks as a single-user system, apps are just directories with anexclamation point in front of the name, and it doesn’t have much in theway of security. RISC OS is also super into drag and drop, where if you wantto save, you drag a “save as” icon to a folder. Basically, it’s a baffling littleoperating system, but it’s fascinating nonetheless.

Most people should not install RISC OS. You can’t really use it as a primaryoperating system, it doesn’t have much in the way of modern softwaresupport, and it doesn’t work like any other operating system available rightnow. That said, it is fun to play around with if you’re the curious type. Forstarter’s guides, Ident Showcase has a good walkthrough on YouTube, theRISC OS welcome page guides you through some basics, or check out theRISC OS forums for tips.

NOOBS is a great way to test out new operating systems and get to knowyour Raspberry Pi, so it’s worthwhile to experiment with all of them a littlebit. If you’re looking for other options, there are a ton of other ready-madeprojects not included on NOOBS that are worth a look.

http://www.kurzweilai.net/more-evidence-that-youre-a-mindless-robot-with-no-free-will

More evidence that you’re a mindless robot with no free will

How we may confabulate reality and rationalize irrational behavior
May 4, 2016

(credit: iStock)

The results of two Yale University psychology experiments suggest that what we believe to be a conscious choice may actually be constructed, or confabulated, unconsciously after we act — to rationalize our decisions. A trick of the mind.

“Our minds may be rewriting history,” said Adam Bear, a Ph.D. student in the Department of Psychology and lead author of a paper published April 28 in the journal Psychological Science.

Tricks of the mind

A model of “postdictive” choice. Although choice of a circle is not actually completed until after a circle has turned red, the choice may seem to have occurred before that event because the participant has not yet become conscious of the circle’s turning red. The circle’s turning red can therefore unconsciously bias a participant’s choice when the delay is sufficiently short. (credit: Adam Bear and Paul Bloom/Psychological Science)

Bear and Paul Bloom performed two simple experiments to test how we experience choices. In one experiment, participants were told that five white circles would appear on the computer screen in front of them and, in rapid-fire sequence, one would turn red. They were asked to predict which one would turn red and mentally note this. After a circle turned red, participants then recorded by keystroke whether they had chosen correctly, had chosen incorrectly, or had not had time to complete their choice.

The circle that turned red was always selected by the system randomly, so probability dictates that participants should predict the correct circle 20% of the time. But when they only had a fraction of a second to make a prediction, these participants were likely to report that they correctly predicted which circle would change color more than 20% of the time.

In contrast, when participants had more time to make their guess — approaching a full second — the reported number of accurate predictions dropped back to expected levels of 20% success, suggesting that participants were not simply lying about their accuracy to impress the experimenters.

(In a second experiment to eliminate artifacts, participants chose one of two different-colored circles, with similar results.)

Confabulating reality

What happened, Bear suggests, is that events were rearranged in subjects’ minds: People unconsciously perceived the color red from the screen image before they predicted it would appear, but then right after that, consciously experienced these two things in the opposite order.

Bear said it is unknown whether this “postdictive” illusion is caused by a quirk in perceptual processing that can only be reproduced in the lab, or whether it might have “far more pervasive effects on our everyday lives and sense of free will.”

Previous research at Charité–Universitätsmedizin Berlin suggests the latter, and includes volition. That research involved a “duel” game between a human and a brain-computer interface (see Do we have free will?). It showed that there‘s a “point of no return” in the decision-making process (at about 200 milliseconds before actual movement onset), after which cancellation of a person’s movement is no longer possible.


Abstract of A Simple Task Uncovers a Postdictive Illusion of Choice

Do people know when, or whether, they have made a conscious choice? Here, we explore the possibility that choices can seem to occur before they are actually made. In two studies, participants were asked to quickly choose from a set of options before a randomly selected option was made salient. Even when they believed that they had made their decision prior to this event, participants were significantly more likely than chance to report choosing the salient option when this option was made salient soon after the perceived time of choice. Thus, without participants’ awareness, a seemingly later event influenced choices that were experienced as occurring at an earlier time. These findings suggest that, like certain low-level perceptual experiences, the experience of choice is susceptible to “postdictive” influence and that people may systematically overestimate the role that consciousness plays in their chosen behavior.

http://www.kurzweilai.net/astronomers-discover-potentially-habitable-planets-just-40-light-years-from-earth

Astronomers discover potentially habitable planets just 40 light years from Earth

Best targets so far for search for extraterrestrial life
May 3, 2016

This artist’s rendering shows an imagined view of the three planets orbiting an ultracool dwarf star just 40 light-years from Earth that were discovered using the TRAPPIST telescope at ESO’s La Silla Observatory. In this view, one of the inner planets is seen in transit (black dot) across the disc of its tiny and dim parent star. (credit: M. Kornmesser/ESO)

Astronomers have detected three exoplanets just 40 light years from Earth whose sizes and temperatures are comparable to those of Earth. The planets may be the best targets found so far for the search for life outside the solar system.

The results were published Monday (May 2) in the journal Nature.

Because the system is relatively close to Earth, co-author Julien de Wit, a postdoc at MIT, says scientists will soon be able to study the planets’ atmospheric compositions, as well as assess their habitability and whether life actually exists within this planetary system.

The scientists discovered the planets using TRAPPIST (TRAnsiting Planets and PlanetesImals Small Telescope), a 60-centimeter telescope operated by the University of Liège, based in Chile. Built by lead authors Michael Gillon and Emmanuel Jehin of the University of Liège, TRAPPIST is designed to focus on 60 nearby small, ”ultracool” dwarf stars (those with effective temperatures of less than 2,700 kelvin) — stars that are so faint they are invisible to optical telescopes and are monitored at infrared wavelengths.

The team focused the telescope on the dwarf star, which they named TRAPPIST-1 — a Jupiter-sized star that is one-eighth the size of our sun and significantly cooler. Over several months, the scientists observed the star’s infrared signal fade slightly at regular intervals, suggesting that several objects were passing in front of the star.

Most exoplanetary missions have been focused on finding systems around bright, solar-like stars. These stars emit radiation in the visible band and can be seen with optical telescopes. However, because these stars are so bright, their light can overpower any signal coming from a planet. Ultracool stars emit radiation in the infrared band. Because they are so faint, these tiny red stars would not drown out the image of a planet crossing the star, giving scientists a better chance of detecting orbiting planets.

May be in the habitable zone

From their observations, the scientists determined that all three planets are likely tidally locked, with permanent day and night sides.

The two innermost planets orbit the star in 1.5 and 2.4 days and receive only four and two times, respectively, the amount of radiation the Earth receives from the sun. The third planet may orbit the star in anywhere from four to 73 days, and may receive even less radiation than Earth. But given their size and proximity to their star, all three planets may have regions with temperatures well below 127 degrees C (260 degrees F), within a range that is suitable for sustaining liquid water and life.

The two planets closest to the star may have day sides that are too hot, and night sides too cold, to host any life forms. However, there may be a “sweet spot” — a region that still receives daylight, but with relatively cool temperatures — on the western side of both planets that may be temperate enough to sustain conditions suitable for life. The third planet, furthest from its star, may be entirely within the habitable zone.

“Now we have to investigate if they’re habitable,” de Wit says. “We will investigate what kind of atmosphere they have, and then will search for biomarkers and signs of life. We have facilities all over the globe and in space that are helping us, working from UV to radio, in all different wavelengths to tell us everything we want to know about this system.”

This research was funded, in part, by the Belgian Fund for Scientific Research, the European Research Council, and NASA.


Abstract of Temperate Earth-sized planets transiting a nearby ultracool dwarf star

Star-like objects with effective temperatures of less than 2,700 kelvin are referred to as ‘ultracool dwarfs’. This heterogeneous group includes stars of extremely low mass as well as brown dwarfs (substellar objects not massive enough to sustain hydrogen fusion), and represents about 15 per cent of the population of astronomical objects near the Sun. Core-accretion theory predicts that, given the small masses of these ultracool dwarfs, and the small sizes of their protoplanetary disks, there should be a large but hitherto undetected population of terrestrial planets orbiting them—ranging from metal-rich Mercury-sized planets to more hospitable volatile-rich Earth-sized planets. Here we report observations of three short-period Earth-sized planets transiting an ultracool dwarf star only 12 parsecs away. The inner two planets receive four times and two times the irradiation of Earth, respectively, placing them close to the inner edge of the habitable zone of the star. Our data suggest that 11 orbits remain possible for the third planet, the most likely resulting in irradiation significantly less than that received by Earth. The infrared brightness of the host star, combined with its Jupiter-like size, offers the possibility of thoroughly characterizing the components of this nearby planetary system.

http://www.kurzweilai.net/the-worlds-tiniest-most-powerful-nanoengine

The world’s tiniest, most powerful nanoengine

Could lead to nanorobots small enough to enter living cells to fight disease
May 3, 2016

Exploding polymer-coated gold nanoparticles in the world’s tiniest engine (credit: Yi Ju/University of Cambridge NanoPhotonics)

University of Cambridge researchers have developed the world’s tiniest engine, capable of a force per unit-weight nearly 100 times higher* than any motor or muscle.

The new nano-engines could lead to nanorobots small enough to enter living cells to fight disease, the researchers say.

Professor Jeremy Baumberg from the Cavendish Laboratory, who led the research, has named the devices “actuating nanotransducers” (ANTs). “Like real ants, they produce large forces for their weight,” he quipped.

As reported in the journal PNAS, the prototype ANT device —  just a few billionths of a meter in size — is made of gold nanoparticles bound together with temperature-responsive gel polymers. It can function as a piston or spring and works in a reversible cycle. Loose nanoparticles in water are first heated. When the temperature reaches 32 degrees C, they suddenly aggregate into a tight ball. Cooling causes the nanoparticles to rapidly take on water and expand in a sudden explosion.

The ANT reversible cycle. Left: ANTs are created by adding a polymer (gray spheres) called pNIPAM to gold nanoparticles (yellow). A blue-light laser then heats the ANT solution. When heated to 32 degrees C with a laser, the polymer nanoparticles absorb large amounts of elastic energy in a fraction of a second as the polymer coatings expel all the water from the gel and collapse, forcing the gold nanoparticles to bind together into dehydrated tight clusters (right). When the device is cooled (by turning off the laser), the polymers rapidly take on water and expand. That strongly, rapidly, and explosively pushes the gold nanoparticles apart — suddenly releasing energy, similar to release of a tightly compressed spring. (credit: Tao Ding et al./PNAS, adapted)

“It’s like an explosion,” said Tao Ding, PhD., from Cambridge’s Cavendish Laboratory, and the paper’s first author. “We have hundreds of gold balls flying apart in a millionth of a second when water molecules inflate the polymers around them.”

This “explosion” process converts Van de Waals energy — the attraction or repulsion between atoms or molecules — into the elastic energy of polymer molecules and releases it very quickly. “The whole process is like a nano-spring,” explained Baumberg. “The smart part here is we make use of Van de Waals attraction of heavy metal particles to set the springs (polymers) and water molecules to release them, which is very reversible and reproducible.”

Biological, other applications

KurzweilAI has covered a number of kinetic nanorobotic and microrobotic devices, including 3D-motion nanomachines from DNA, a magnetically controlled “nanoswimmer” for delivering drugs, sperm-inspired microrobots controlled by magnetic fields, and bacteria-powered microrobots.  However, the forces exerted by ANT devices are several orders of magnitude larger* than those for any other previously produced device, according to the researchers. ANT devices are bio-compatible, cost-effective to manufacture, fast to respond, and energy-efficient, according to the researchers.

Possible applications include microrobotics, sensing, storage devices, smart windows and walls, and especially biomedical uses, since the spring process occurs at biological temperatures (32 degrees C or 90 degrees F). The team plans to initially commercialize this technology for optically controlled biological microfluidic pumps and valves.

The research is funded as part of a UK Engineering and Physical Sciences Research Council (EPSRC) investment in the Cambridge NanoPhotonics Centre, and by the European Research Council (ERC).

* On the order of nN compared to typically 10 fN/nm2, with up to GHz switching speeds.


Abstract of Light-induced actuating nanotransducers

Nanoactuators and nanomachines have long been sought after, but key bottlenecks remain. Forces at submicrometer scales are weak and slow, control is hard to achieve, and power cannot be reliably supplied. Despite the increasing complexity of nanodevices such as DNA origami and molecular machines, rapid mechanical operations are not yet possible. Here, we bind temperature-responsive polymers to charged Au nanoparticles, storing elastic energy that can be rapidly released under light control for repeatable isotropic nanoactuation. Optically heating above a critical temperature Tc = 32 °C using plasmonic absorption of an incident laser causes the coatings to expel water and collapse within a microsecond to the nanoscale, millions of times faster than the base polymer. This triggers a controllable number of nanoparticles to tightly bind in clusters. Surprisingly, by cooling below Tc their strong van der Waals attraction is overcome as the polymer expands, exerting nanoscale forces of several nN. This large force depends on van der Waals attractions between Au cores being very large in the collapsed polymer state, setting up a tightly compressed polymer spring which can be triggered into the inflated state. Our insights lead toward rational design of diverse colloidal nanomachines.

http://www.kurzweilai.net/ibm-makes-quantum-computing-available-free-on-ibm-cloud

IBM makes quantum computing available free on IBM Cloud

You can run real or simulated experiments on an IBM quantum processor
May 3, 2016

Layout of IBM’s five superconducting quantum bit device. In 2015, IBM scientists demonstrated critical breakthroughs to detect quantum errors by combining superconducting qubits in latticed arrangements, and whose quantum circuit design is the only physical architecture that can scale to larger dimensions. Now, IBM scientists have achieved a further advance by combining five qubits in the lattice architecture, which demonstrates a key operation known as a parity measurement — the basis of many quantum error correction protocols. (credit: IBM Research)

IBM Research has announced that effective Wednesday May 4, it is making quantum computing available free to members of the public, who can access and run experiments on IBM’s quantum processor, via the IBM Cloud, from any desktop or mobile device.

IBM believes quantum computing is the future of computing and has the potential to solve certain problems that are impossible to solve on today’s supercomputers.

The cloud-enabled quantum computing platform, called IBM Quantum Experience, will allow users to run algorithms and experiments on IBM’s quantum processor, work with the individual quantum bits (qubits), and explore tutorials and simulations around what might be possible with quantum computing.

The quantum processor is composed of five superconducting qubits and is housed at the IBM T.J. Watson Research Center in New York. IBM’s quantum architecture can scale to larger quantum systems. It is aimed at building a universal quantum computer that can be programmed to perform any computing task and will be exponentially faster than classical computers for a number of important applications for science and business, IBM says.


IBM | Explore our 360 Video of the IBM Research Quantum Lab

IBM envisions medium-sized quantum processors of 50–100 qubits to be possible in the next decade. With a quantum computer built of just 50 qubits, none of today’s TOP500 supercomputers could successfully emulate it, reflecting the tremendous potential of this technology.

“Quantum computing is becoming a reality and it will extend computation far beyond what is imaginable with today’s computers,” said Arvind Krishna, senior vice president and director, IBM Research. “This moment represents the birth of quantum cloud computing. By giving hands-on access to IBM’s experimental quantum systems, the IBM Quantum Experience will make it easier for researchers and the scientific community to accelerate innovations in the quantum field, and help discover new applications for this technology.”

This leap forward in computing could lead to the discovery of new pharmaceutical drugs and completely safeguard cloud computing systems, IBM believes. It could also unlock new facets of artificial intelligence (which could lead to future, more powerful Watson technologies), develop new materials science to transform industries, and search large volumes of big data.

The IBM Quantum Experience


IBM | Running an experiment in the IBM Quantum Experience

Coupled with software expertise from the IBM Research ecosystem, the team has built a dynamic user interface on the IBM Cloud platform that allows users to easily connect to the quantum hardware via the cloud.

In the future, users will have the opportunity to contribute and review their results in the community hosted on the IBM Quantum Experience and IBM scientists will be directly engaged to offer more research and insights on new advances. IBM plans to add more qubits and different processor arrangements to the IBM Quantum Experience over time, so users can expand their experiments and help uncover new applications for the technology.

IBM employs superconducting qubits that are made with superconducting metals on a silicon chip and can be designed and manufactured using standard silicon fabrication techniques. Last year, IBM scientists demonstrated critical breakthroughs to detect quantum errors by combining superconducting qubits in latticed arrangements, and whose quantum circuit design is the only physical architecture that can scale to larger dimensions.


IBM | IBM Brings Quantum Computing to the Cloud

Now, IBM scientists have achieved a further advance by combining five qubits in the lattice architecture, which demonstrates a key operation known as a parity measurement — the basis of many quantum error correction protocols.

By giving users access to IBM’s experimental quantum systems, IBM believes it will help businesses and organizations begin to understand the technology’s potential, for universities to grow their teaching programs in quantum computing and related subjects, and for students (IBM’s potential future customers) to become aware of promising new career paths. And of course, to raise IBM’s marketing profile in this emerging field.

http://www.telegraph.co.uk/science/2016/05/04/artificial-womb-breakthrough-sparks-row-over-how-long-human-embr/

‘Artificial womb’ breakthrough sparks row over how long human embryos should be kept in lab

  • An ethical debate over how long human embryos can be grown in a lab has erupted after Cambridge University announced it had allowed fertilised eggs to mature for 13 days – just one day short of the legal limit.

    In groundbreaking research, scientists invented a thick soup of nutrients which mimics conditions in the womb, and keeps an embryo alive for days longer than it could previously survive without being implanted into a mother.

    Currently UK law bans laboratories for growing embryos for longer than 14 days because after two weeks, twins can no longer form, and so it is deemed that an individual has started to develop.

    But scientists have now suggested that the deadline should be extended to allow for more research into the development of embryos.

    Professor Magdalena Zernicka-Goetz, who led the research suggested it would be useful to extend the limit by a few days, while Professor Robert Lovell-Badge of London’s Francis Crick Institute said an extra week might be useful, but admitted it could ‘open a can of worms.’

    “Proposing to extend the 14-day limit might be opening a can of worms, but would it lead to Pandora’s box, or a treasure chest of valuable information ?” said Professor Lovell-Badge

    “This is not a question to be left to scientists alone.”

    An embryo at day 11
    An embryo at day 11 CREDIT: UNIVERSITY OF CAMBRIDGE 

    The Nuffield Council on Bioethics is holding a meeting later in the year to discuss the possibility of changing the limit.

    Chairman Johnathon Montgomery said: “The Council intends to bring together invited participants with a range of perspectives on embryo research in order to evaluate whether, after 25 years, there may be persuasive reasons to review this legal limit, or whether the reasons for its introduction remain sound.”

    The two week limit was first established in the Warnock Report which was published in 1984, and concluded that it was ethical to conduct research on human embryos until day 14 of their development. It was enshrined in law in the 1991 Human Fertilisation and Embryology Act.

    But until now the legal restriction has been largely theoretical as no one had the technical means to keep embryos alive in the laboratory beyond a week.

    In a paper published in the journal Nature, Cambridge Universityshowed that it is possible to force the embryo to attach to a culture material, and begin dividing into groups of cells which will eventually form the foetus, placenta and yolk sac, just like in the womb.

    Previously an embryo had to implant in the womb by day seven to survive, but it is impossible to see what is happening inside the mother at this stage, so scientists were in the dark about the cellular and molecular changes taking place.

    Crucially it is during that period that two thirds of pregnancies fail because the embryo does not implant properly.

    Now that scientists can see the steps needed for healthy embryo development it will help them understand why things go wrong, potentially improving IVF rates.

    “It is a most enigmatic and mysterious period of our development which we have never had any access to,” said lead author Professor Zernicka-Goetz.

    “Implantation is a milestone in human development as it is from this stage onwards that the embryo really begins to take shape and the overall body plan are decided

    “It is also the stage of pregnancy at which many developmental defects can become acquired. But until now, it has been impossible to study this in human embryos.”

    The embryo was shown to split into two parts with cavities 
    The embryo was shown to split into two parts with cavities  CREDIT: NATURE 

    However the technical challenge of allowing an embryo to survive past 14 days is also tricky and has never been successful, even in mouse. As it grows to the next stage, an embryo needs to get rid of waste, and scientists do not know how to make that happen.

    Professor Azim Surani, Director of Germline and Epigenomics Research, The Gurdon Institute, said: “There might be technical challenges to getting the embryos go through gastrulation, that is when single layered epiblast develops into trilaminar structure and the Carnegie stage when primordial germ cells, precursors of sperm and eggs are also established.

    “The regulatory framework would need to be looked at so that the embryos can be cultured beyond the 14 day limit. In my opinion, there has been a case to allow culture beyond 14 days even before these papers appeared.”

    Professor Daniel Brison, Honorary Professor of Clinical Embryology at  University of Manchester, said that allowing a later cut off point could help prevent miscarriages and pregnancy disorders.

    “This limit was chosen more than 20 years ago as it was thought to represent the first point when individuality is assigned and twinning no longer possible, and carries strong support in the UK from patients and researchers.

    “However, given the potential benefits of new research in infertility, improving assisted conception methods, and in early miscarriage and disorders of pregnancy, there may be a case in the future to reconsider this.”

    However leading fertility expert, Allan Pacey, Professor of Andrology at the  University of Sheffield, said the 14 day rule did not need to be changed for research to progress,

    “It will not open the door to couples being able to grow babies in the laboratory; this is not the dawn of a Brave New World scenario.

    “But it does open up exciting opportunities to understand the nature of human disease and disability and for that reason the scientists involved should be congratulated.”

    Josephine Quintavalle, Director of Comment on Reproductive Ethics (Core), said: “The natural place for a human being to be is not in a petri dish and is not in a laboratory.

    “We’ve always said no to these experiments. Pro life means you protect human life – there’s no protection being in a petri dish being experimented on.”

    The embryos used in the study were donated by IVF patients.

 

http://www.ctvnews.ca/health/vitamin-found-to-delay-aging-process-in-organs-1.2885322

Vitamin found to delay aging process in organs

Vitamin found to delay aging processNicotinamide riboside (NR) could help stop the ageing process in organs. (stock_colors/Istock.com)

An international study, published in the journal Science has led to a promising breakthrough in the field of anti-aging medicine. A vitamin called nicotinamide riboside (NR) — already known to boost metabolism — has been found to restore the body’s ability to regenerate and repair itself.

The regenerative capacity of cells and organs deteriorates with age. The “powerhouses” of cell function — called mitochondria — lose energy over time and prevent cells from regenerating as they once did.

Research teams from Switzerland, Canada and Brazil studied how these changes occur over time. The role of mitochondria in metabolism has already been identified, but the scientists were able to demonstrate for the first time that healthy, functioning mitochondria were important for stem cell function.

The study set out to revitalize stem cells in the muscles of elderly mice by giving them nicotinamide riboside (NR). This substance is close to vitamin B3 and is a precursor of NAD+, a molecule that plays a key role in the activity of mitochondria. NAD+ levels can be diminished by the stress related to aging.

The findings, published in the journal Science, proved highly promising. Muscular regeneration was found to be much better in mice that were given NR. These mice also lived longer than those not given NR. As yet, no negative side effects have been observed from NR use, even at high doses.

The NR vitamin has been discovered in milk. It’s also thought to be found in beer, but the nutrient’s presence is very difficult to measure and quantify. In fact, it’s not yet known precisely which foods contain NR or in what quantities, the specialists explain. The compound is currently on sale in the form of dietary supplements, but as yet there are no scientific guidelines recommending their use.

For the researchers, the study represents a major breakthrough for regenerative medicine, highlighting a potential future means of reestablishing the body’s own ability to repair itself with a dietary supplement.

The findings also hold promising possibilities for the treatment of potentially fatal conditions affecting young people, like muscular dystrophy (a form of myopathy).

However, more detailed studies are required to investigate the action of this substance on pathological cells.

http://www.military-technologies.net/2016/05/03/sinequa-ushers-in-the-era-of-cognitive-computing-with-new-version-of-its-cognitive-insight-platform/

SINEQUA USHERS IN THE ERA OF COGNITIVE COMPUTING WITH NEW VERSION OF ITS COGNITIVE INSIGHT PLATFORM

Cognitive Search & Powerful Analytics Provide Deep INSIGHTs in Data and User Behavior Using Machine Learning

NEW YORK – May 3, 2016Sinequa today announced the general availability of Sinequa ES Version 10. Powered by Machine Learning capabilities at its core, this ground breaking version helps deliver deep analytics of contents and user behavior, offering information with continually improving relevance to users in their work environments. The self-learning platform makes information self-service a reality, even for non-experts, while keeping it simple for administrators to manage.

Sinequa logo

Sinequa logo

“Cognitively enabled applications, especially those dealing with unstructured data, are clearly the future for better information delivery to users in a wide range of industries and work environments,” said David Schubmehl, Research Director at IDC. “By 2020, 50% of all business analytics software will include prescriptive analytics built on cognitive computing functionality.”

In order to achieve the quantum leap into the world of Cognitive Computing with this new version, Sinequa has integrated the Spark platform in its distributed architecture and implemented Machine Learning algorithms on Spark within the core of its product.

“Our law firm has built a system leveraging Sinequa’s Search & Analytics platform to get insight about our experience from millions of records and documents including attorney biographies, subject matter summaries, time notes/billable hours and more. We are excited about this new version with Machine Learning based on Spark and look forward to the added value it can provide to us,” said Harris Tilevitz, CTO at Skadden, Arps, Slate, Meagher & Flom LLP. With nearly 1,700 attorneys, Skadden, Arps, Slate, Meagher & Flom LLP is one of the highest-grossing law firms in the world.

Sinequa has implemented and fine-tuned these algorithms to ensure high performance and the best possible integration with its platform. The Machine Learning algorithms continually analyze and enrich the content of the Sinequa Logical Data Warehouse. The new Cognitive Search & Analytics platform offers better insights and more relevant information to meet users’ expectations. As always with Sinequa, the new functionalities require minimal user efforts while offering intelligent tuning capabilities to administrators.

“This new version is a leap forward into the era of ‘cognitive computing’ or ‘insight engines,’ to use the terminology coined by leading market analysts,” stated Alexandre Bilger, CEO, Sinequa. “In dealing with Big Data and its rapid growth, leading data-driven organizations need to rely on intelligent and self-learning systems to analyze data and find valuable information for their employees, thus increasing their productivity and job satisfaction, and the company’s competitiveness. Our Machine Learning capabilities achieve these goals by including Collaborative FiLTEring and Recommendations, Classification by Example, Clusterization and Similarity calculations for unstructured contents, and Predictive Analysis.”

The new Sinequa ES V10 also includes innovative features that have proved useful in customer projects and that represent strong emerging trends: Sinequa is now a “native resident” of cloud platforms, such as Amazon Web Services and Microsoft Azure, optimizing the use of resources of those platforms. Industry specific dictionaries and ontologies from partners like Scibite and Linguamatics have been integrated for customers in Life Science and Health Care. Google Vision and Microsoft Azure Media Services are also leveraged in order to deal more effectively with images as well as videos. Google Translate is used for automated translation between over 100 languages. With 150+ ready-to-use connectors and growing, Sinequa continues to broaden connectivity for rapid extraction of valuable insights from Enterprise Applications, Hadoop and Cloud environments.

For more information about Sinequa ES V10 – please visit www.sinequa.com/insight-platform.

About Sinequa
Recognized as a leader in the Gartner 2015 Magic Quadrant for Enterprise Search and The Forrester Wave™: Big Data Search and Knowledge Discovery Solutions, Sinequa provides a Cognitive Search & Analytics platform for Fortune Global 2000 companies and government agencies. Using advanced Natural Language Processing (NLP) and Machine Learning algorithms, the solution offers insights extracted from structured and unstructured data. Millions of users in the world’s largest and most information-intensive organizations, including Airbus, AstraZeneca, Atos, Biogen, UCB, Credit Agricole, Mercer, and Siemens, rely on Sinequa to put business-critical information at the fingertips of their employees. Sinequa develops its expertise and its business around the world with a broad network of technology and business partners. Sinequa is a founding sponsor of the Cognitive Computing Consortium. For more information,http://www.sinequa.com.